Sunday, 13 December 2015

Basic Pharmacology Objective Type Questions And Answers

21- A 43 year old woman with atopic dermatitis (atopic eczema) presented with an acute generalized exacerbation of her disease. She was admitted to hospital but failed to improve with emollients, topical betamethasone-17-valerate and oral antihistamine. Which one of the following drugs is the most appropriate treatment?
1) Acitretin
2) Amoxycillin
3) Ciclosporin
4) Colchicine
5) Dapsone

22- A 30-year-old man presents to the Accident and Emergency Department with a history of drug overdose. He is known to be repeatedly admitted with similar episodes of self-harm. On this occaision he is drowsy and has prominent hypersalivation. Which of the following agents, found on his person, is the likely cause?
1) Chlormethiazole
2) Cocaine
3) Dothiepin
4) L-dopa
5) Solvent cannister

23- Which of the following is a contraindication to immunisation?
1) Infantile eczema requiring topical steroids.
2) Oral poliomyelitis vaccine to a child on oral steroids.
3) A history of prolonged jaundice.
4) A child with congenital adrenal hyperplasia on oral cortisone.
5) A child with cerebral palsy.

24- In which of the following cases would the level of the second drug (or its effect) become elevated by adding the first?
1) Erythromycin : theophylline
2) Phenytoin : ethynoloestrodial
3) Ranitidine : cortiocosteroid
4) Rifampicin : warfarin
5) Valproate : phenobarbitone

25- Which of the following is true concerning oral hypoglycaemic agents?
1) Acarbose promotes insulin secretion in response to meals
2) Chlorpropamide induces liver enzymes
3) Glibenclamide is excreted unchanged by the kidney
4) Gliclazide inhibits gluconeogenesis
5) Metformin inhibits hepatic gluconeogenesis

26- A 44 year old male with Child's grade C cirrhosis presented with haematemesis. Which one of the following drugs, administered intravenously, would be the most appropriate, immediate, treatment?
1) Isosorbide dinitrate.
2) Omeprazole.
3) Propranolol
4) Somatostatin
5) Tranexamic acid.

27- A 25 year old male homosexual is admitted with dyspnoea and weight loss of 2 months duration. He is diagnosed with Pneumocystis pneumoniae due to AIDS. Which of the following concerning Pneumocystis pneumonia is true?
1) May have an extra pulmonary presentation
2) is always associated with X-ray changes
3) is caused by a bacterium
4) elevated serum antibodies to P. carinii helpful diagnostically
5) is best treated with intravenous pentamidine

28- A 68-year-old lady with mitral valve disease and atrial fibrillation is taking warfarin. Lately her INR has fallen and the dose of warfarin has had to be increased. Which of the following new treatments may account for this change?
1) Allopurinol
2) Amiodarone
3) Clarithromycin
4) Sertraline
5) St John's wort

29- You are an occupational health physician and have been asked by an anxious employee about contraindications to pertussis immunisation. Which of the following is a contraindication?
1) Eczema
2) Cow's milk protein intolerance.
3) Fever to 39.5°C following the first dose.
4) Redness of >2.5cm at the injection site after the first dose.
5) Hydrocephalus

30 - Which of the following is true regarding the action of Clopidogrel?
1) It inhibits cyclo-oxygenase
2) It is an ADP receptor antagonist
3) It is a glycoprotein IIb/IIIa inhibitor
4) It is a selective factor Xa inhibitor
5) It is Hydroxymethyl Coenzyme A inhibitor

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