Sunday, 13 December 2015

Tricky Pharmacology Objective Type Questions And Answers

41- Which one of the following is a recognised treatment option in poisoning?
1) ethanol for isopropyl alcohol poisoning
2) glucagon for cocaine poisoning
3) methylene blue for cyanide poisoning
4) N-acetylcysteine in paraquat poisoning
5) pralidoxime in sarin (nerve gas) poisoning

42- A 78 year old female is referred by her GP with high blood pressure. Over the last three months her blood pressure is noted to be around 180/80 mmHg. She has a body mass index of 25.5kg/m2, is a nonsmoker. There are no features to suggest a secondary cause for her hypertension.
Which of the following is the most appropriate treatment for her blood pressure?
1) Alpha-Blocker
2) Angiotensin Converting Enzyme (ACE) Inhibitor
3) Angiotensin Blocker
4) Beta-blocker
5) Calcium channel blocker

43- A 56 year old male with left ventricular systolic dysfunction was dyspnoeic on climbing stairs but not at rest. The patient was commenced on ramipril and frusemide. Which one of the following drugs would improve the patient's prognosis?
1) Amiodarone
2) Amlodipine
3) Bisoprolol
4) Digoxin
5) Nitrate therapy

44- A 70 year old female is admitted 12 hours after taking an overdose of aspirin. Investigations revealed: Serum sodium 138 mmol/L (137-144), Serum potassium 5.9 mmol/L (3.5-4.9), Serum bicarbonate 14 mmol/L (20-28), Serum urea 18.1 mmol/L (2.5-7.5), Serum creatinine 238 umol/L (60-110), Serum salicylate 1120 mg/L (8 mmol/L). What is the most appropriate treatment of this patient?
1) Haemodialysis
2) Haemofiltration
3) Intravenous sodium bicarbonate.
4) Peritoneal dialysis.
5) Urine alkalinization.

45- A 40-year-old man attending a routing screening has a blood pressure of 166/100 mmHg. Two weeks later his blood pressure was 150/90 mmHg. He does not smoke. He drinks 35 units alcohol / week. His body mass index (BMI) is 30 kg/m2 (20 - 25). What is the best management strategy?
1) amlodipine
2) atenolol
3) bendrofluazide
4) enalapril
5) lifestyle advice

46- In a chronic disease which has no known effective treatment, a new treatment is known to be effective in animal models and shows promise in short-term studies in patients. There are some theoretical concerns about toxicity involving liver and bone marrow although no cases have been observed in studies so far. What is the most appropriate next step in the drug's development?
1) case control study
2) No further studies should be done and drug development should be stopped
3) open study
4) randomised double blind placebo controlled study
5) randomised single blind placebo controlled study

47- Which of the following compounds has a vasodilating effect?
1) Antidiuretic hormone
2) Calcitonin
3) Endothelin
4) Renin
5) Somatostatin

48- In malignant hyperpyrexia:
1) A mortality rate of 20% may be expected
2) Elevation of serum creatine kinase and myoglobinuria is diagnostic
3) Muscle biopsy may be histologically normal
4) The only available specific treatment is sodium dantrolene, which has a neutral pH
5) The predisposing gene is thought to be on chromosome 9

49- Which of the following anti-microbials is associated with prolongation of the QT interval?
1) Co-amoxiclav
2) Gentamicin
3) Cefuroxime
4) Erythromycin
5) Isoniazid

50- A study has been designed to investigate whether a certain drug plus physiotherapy treatment is better than drug treatment alone in the management of rheumatoid arthritis. After randomizing the patients a small proportion of the drug plus physiotherapy group decide to drop out of the study or omit some treatment sessions specified in the research protocol. What is the correct way of analysing the subsequent data?
1) Assume the patients have withdrawn their consent
2) Exclude these patients from all analysis
3) Extend the trial recruitment to make up the numbers
4) Include these patient outcomes in the drug plus physiotherapy group
5) Interview the patients and report their group separately

More Questions & Answers:-
Page1 Page2 Page3 Page4 Page5 Page6 Page7 Page8 Page9

No comments:

Post a Comment