Friday, 8 January 2016

Experienced Bio-technology Interview Questions and Answers

31. How many types of histamine receptors are there and what are they?
There are three types of histamine receptors. They are H1, H2 and H3.They has different tissue distributions.

32. What is the reaction-taking place when H2 receptor binds to mast cells and basophils?
When H2 binds to mast cells and basophils it suppresses degranulation.

33. Explain in brief about leukotrienes and prostaglandins
Leukotrienes and prostaglandins are formed only when the mast cell undergo degranulation and enzymatic break down of phospholipids in the plasma membrane.
The effects produced by them are more pronounced and long lasting than histamine. Leukotrienes mediate mucous production and bronchoconstriction. Prostaglandin D2 causes bronchoconstriction.

34. Explain in brief about cytokines
Cytokines activate inflammatory cells such as neutrophils and eosnophils.IL-5 is important in activation of eosnophils, IL-4 increases IgE production by B-cells. IL-4, Il-5, IL-6, TNF-a has been secreted by human mast cells.

35. What is atopic dermatitis?
Atopic dermatitis is an inflammatory skin disease. This disease is observed frequently in young children. There will be skin eruptions.

36. What is erythroblastosis fetalis?
It is a hemolytic disease, which develops in newborn. Maternal IgG antibodies cross the placenta and destroy the red bleed cells. This develops when an Rh+ expresses an Rh antigen on blood cells that the mother does not express.

37. What is a rhogam?
Is an antibody that binds to any of the blood cells, enter the mother’s blood circulation, and facilitate their clearance by activation of B-cells and memory cell production.

38. What is type I hypersensitivity?
It is IgE mediated hypersensitivity. Typical manifestations include asthma, food allergies, eczema, hay fever etc.

39. What is type II hypersensitivity?
It is IgG mediated cytotoxic hypersensitivity. Typical manifestations include erythroblastosis fetalis, hemolytic anemia, blood transfusion reactions etc.

40. What is type III hypersensitivity?
It is immune complex mediated hypersensitivity. Typical manifestations include rheumatoid arthritis, serum sickness, necrotizing etc.

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