Thursday, 29 October 2015

Latest Drugs Acting On Central Nervous System Objective Type Questions And Answers

61. Following is an excitatory amino acid receptor antagonist?
(a) Phencyclidine
(b) Quisqualate
(c) Homocysteate
(d) Kainate
Ans: A

62. Which one of the following drugs has spasmolytic activity and could also be used in the management of seizures caused by overdose of a local anesthetic?
(a) Baclofen
(b) Cyclobenzaprine
(c) Dantrolene
(d) Diazepam
(e) Tizanidine
Ans: D

63. Which one of the following drugs given preoperatively will prevent postoperative pain caused by succinylcholine?
(a) Baclofen
(b) Dantrolene
(c) Diazepam
(d) Lidocaine
(e) Tubocurarine
Ans: E

64. As the physician, you could tell the patient (and close family members) all of the following things about levodopa except?
(a) Taking the drug in divided doses will decrease nausea and vomiting
(b) He should be careful when he stands up because he may get dizzy
(c) Uncontrollable muscle jerks may occur
(d) A net-like reddish to blue discoloration of the skin is a likely side effect of the medication
(e) The drug will probably improve his symptoms for a period of time but not indefinitely
Ans: D

65. As the physician who is prescribing levodopa, you will note that the drug
(a) Causes less severe behavioral side effects if given with carbidopa
(b) Fluctuates in its effectiveness with increasing frequency as treatment continues
(c) Prevents extrapyramidal adverse effects of antipsychotic drugs
(d) Protects against cancer in patients with melanoma
(e) Has toxic effects that include pulmonary infiltrates
Ans: B

66. The major reason why carbidopa is of value in parkinsonism is that the compound
(a) Crosses the blood-brain barrier
(b) Inhibits monoamine oxidase type A
(c) Inhibits aromatic L-amino acid decarboxylase
(d) Is converted to the false neurotransmitter carbidopamine
(e) Inhibits monoamine oxidase type B
Ans: C

67. Which one of the following statements about bromocriptine is accurate?
(a) It should not be administered to patients taking antimuscarinic drugs
(b) Effectiveness in Parkinson’s disease requires its metabolic conversion to an active metabolite
(c) The drug is contraindicated in patients with a history of psychosis
(d) The drug should not be administered to patients already taking levodopa
(e) Mental disturbances occur more commonly with levodopa than with bromocriptine
Ans: C

68. A 72-year-old patient with parkinsonism presents with swollen feet. They are red, tender, and very painful. You could clear up these symptoms within a few days if you told the patient to stop taking
(a) Amantadine
(b) Benztropine
(c) Bromocriptine
(d) Levodopa
(e) Selegiline
Ans: C

69. Concerning the drugs used in parkinsonism, which of the following statements is accurate?
(a) Levodopa causes mydriasis and can precipitate an attack of acute glaucoma
(b) Useful therapeutic effects of amantadine continue for several years
(c) The primary therapeutic benefit of antimuscarinic drugs in parkinsonism is their ability to reliever bradykinesia
(d) Dopamine receptor against should not be used in Parkinson’s disease prior to a trial of levodopa
(e) The concomitant use of selegiline may increase the peripheral adverse effects of levodopa
Ans: A

70. A previously healthy 50-year-old woman begins to suffer from slowed mentation and develops writhing movement of her tongue and hands. In addition, she has delusions of being persecuted. The woman has no past history of psychiatric or neurologic disorders. The most appropriate drug for treatment is
(a) Amantadine
(b) Bromocriptine
(c) Haloperidol
(d) Levodopa
(e) Trihexyphenidyl
Ans: C

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