31. The activity of this enzyme is specifically decreased in the Wernicke-Korsakoff syndrome
(a) Alcohol dehydrogenase
(b) Cytochrome P450
(c) L-Aromatic amino acid decarboxylase
(d) NADH dehydrogenase
(e) Pyruvate dehydrogenase
Ans: E
32. Following is glycine antagonists
(a) Quisqualate
(b) Taurine
(c) Strychnine
(d) รข-alanine
Ans: C
33. Which one of the following statements concerning the pharmacokinetics of antiseizure drugs is accurate?
(a) At high doses, phenytoin elimination follows first-order kinetics
(b) Valporic acid may increase the activity of hepatic ALA synthase and the synthesis of porphyrins
(c) The administration of phenytoin to patients in methadone maintenance programs has led to symptoms of opioid overdose, including respiratory depression
(d) Although ethosuximide has a half-life of approximately 40 hours, the drug is usually taken twice a day
(e) Treatment with vigabatrin may reduce the effectiveness of oral contraceptives
Ans: D
34. With chronic use in seizure states, the adverse effects of this drug include coarsening of facial features, hirsutism, gingival hyperplasia, and osteomalacia.
(a) Carbamazepine
(b) Ethosuximide
(c) Gabapentin
(d) Phenytoin
(e) Valproic acid
Ans: D
35. Which one of the following statements about vigabatrin is accurate?
(a) Blocks neuronal reuptake of GABA
(b) Drug of choice in absence seizures
(c) Is established to be teratogenic in humans
(d) Life-threatening skin disorders may occur
(e) Visual field defects occur in up to one-third of patients
Ans: E
36. Withdrawal of antiseizure drugs can cause increased seizure frequency and severity. Withdrawal is least likely to be a problem with
(a) Clonazepam
(b) Diazepam
(c) Ethosuximide
(d) Phenobarbital
(e) Phenytoin
Ans: C
37. A young femal patient who suffers from bipolar affective disorder (BAD) has been managed with lithium. If she becomes pregnant, which one of the following drugs is likely to be effective in bipolar affective disorder with minimal risk of teratogenicity?
(a) Carbamazepine
(b) Clonazepam
(c) Phenytoin
(d) Valproic acid
(e) None of the above
Ans: B
38. The most likely mechanism involved in the antiseizure activity of carbamazepine is
(a) Block of sodium ion channels
(b) Block of calcium ion channels
(c) Facilitation of GABA actions on chloride ion channels
(d) Glutamate receptor antagonism
(e) Inhibition of GABA transaminase
Ans: A
39. Which one of the following statements about phenytoin is accurate?
(a) Displaces sulfonamides from plasma proteins
(b) Drug of choice in myoclonic seizures
(c) Half-life is increased if used with phenobarbital
(d) Isoniazid (INH) decreases steady state blood levels of phenytoin
(e) Toxicity may occur with only small increments in dose
Ans: E
40. Which one of the following statements concerning nitrous oxide is accurate?
(a) It continues to be a useful component of anesthesia protocols because of its lack of cardiovascular depression
(b) Megaloblastic anemia is a common adverse effect in patients exposed to nitrous oxide for periods longer than 2 hours
(c) It is the most potent of the inhaled anaesthetics
(d) There is a direct association between the use of nitrous oxide and malignant hyperthermia
(e) More than 30% of nitrous oxide is eliminated via hepatic metabolism
Ans: A
(a) Alcohol dehydrogenase
(b) Cytochrome P450
(c) L-Aromatic amino acid decarboxylase
(d) NADH dehydrogenase
(e) Pyruvate dehydrogenase
Ans: E
32. Following is glycine antagonists
(a) Quisqualate
(b) Taurine
(c) Strychnine
(d) รข-alanine
Ans: C
33. Which one of the following statements concerning the pharmacokinetics of antiseizure drugs is accurate?
(a) At high doses, phenytoin elimination follows first-order kinetics
(b) Valporic acid may increase the activity of hepatic ALA synthase and the synthesis of porphyrins
(c) The administration of phenytoin to patients in methadone maintenance programs has led to symptoms of opioid overdose, including respiratory depression
(d) Although ethosuximide has a half-life of approximately 40 hours, the drug is usually taken twice a day
(e) Treatment with vigabatrin may reduce the effectiveness of oral contraceptives
Ans: D
34. With chronic use in seizure states, the adverse effects of this drug include coarsening of facial features, hirsutism, gingival hyperplasia, and osteomalacia.
(a) Carbamazepine
(b) Ethosuximide
(c) Gabapentin
(d) Phenytoin
(e) Valproic acid
Ans: D
35. Which one of the following statements about vigabatrin is accurate?
(a) Blocks neuronal reuptake of GABA
(b) Drug of choice in absence seizures
(c) Is established to be teratogenic in humans
(d) Life-threatening skin disorders may occur
(e) Visual field defects occur in up to one-third of patients
Ans: E
36. Withdrawal of antiseizure drugs can cause increased seizure frequency and severity. Withdrawal is least likely to be a problem with
(a) Clonazepam
(b) Diazepam
(c) Ethosuximide
(d) Phenobarbital
(e) Phenytoin
Ans: C
37. A young femal patient who suffers from bipolar affective disorder (BAD) has been managed with lithium. If she becomes pregnant, which one of the following drugs is likely to be effective in bipolar affective disorder with minimal risk of teratogenicity?
(a) Carbamazepine
(b) Clonazepam
(c) Phenytoin
(d) Valproic acid
(e) None of the above
Ans: B
38. The most likely mechanism involved in the antiseizure activity of carbamazepine is
(a) Block of sodium ion channels
(b) Block of calcium ion channels
(c) Facilitation of GABA actions on chloride ion channels
(d) Glutamate receptor antagonism
(e) Inhibition of GABA transaminase
Ans: A
39. Which one of the following statements about phenytoin is accurate?
(a) Displaces sulfonamides from plasma proteins
(b) Drug of choice in myoclonic seizures
(c) Half-life is increased if used with phenobarbital
(d) Isoniazid (INH) decreases steady state blood levels of phenytoin
(e) Toxicity may occur with only small increments in dose
Ans: E
40. Which one of the following statements concerning nitrous oxide is accurate?
(a) It continues to be a useful component of anesthesia protocols because of its lack of cardiovascular depression
(b) Megaloblastic anemia is a common adverse effect in patients exposed to nitrous oxide for periods longer than 2 hours
(c) It is the most potent of the inhaled anaesthetics
(d) There is a direct association between the use of nitrous oxide and malignant hyperthermia
(e) More than 30% of nitrous oxide is eliminated via hepatic metabolism
Ans: A
I was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
ReplyDeleteliver already present. I started on antiviral medications which
reduced the viral load initially. After a couple of years the virus
became resistant. I started on HEPATITIS B Herbal treatment from
ULTIMATE LIFE CLINIC (www.ultimatelifeclinic.com) in March, 2020. Their
treatment totally reversed the virus. I did another blood test after
the 6 months long treatment and tested negative to the virus. Amazing
treatment! This treatment is a breakthrough for all HBV carriers.